A victory at the Juventus stadium in Italy on Tuesday night will see Juventus remain top of the Serie A table, although their hopes of repeating as champions will be further diminished.
Juventus defeated Napoli 4-1, after a goalless draw on Wednesday.
Juventus have now won their last seven league games, a run that began in April.
Their last league win came against Inter Milan in March, when the Bianconeri were eliminated in the Europa League final.
Juve have now beaten Napoli five times in their last six league games.
A victory over Napoli could see them move up to fifth in Serie A, although it is highly unlikely that Juventus will be able to keep hold of the title after losing their first four games in all competitions.
Juventus will need to win two more games in order to maintain their position.
Napoli, meanwhile, will need a draw or victory against Juventus to secure a Champions League place.
Napoli are currently fifth in La Liga, four points behind leaders Real Madrid.
Napola face a difficult game against Juventus in the Champions League group stages, with Sevilla and Inter Milan among the teams that have managed to reach the group stages of the competition.
The last time Napoli were eliminated by Juve was in October 2013, when they lost 2-1 to Inter Milan.
Juarez, meanwhile and Napoli will face off again on Wednesday at the Estadio San Paolo.
Juve, who are currently second in Serie B, lost 4-0 at Sampdoria on Tuesday.
Juvia v Juventus, live on ESPN, Sky Sports and BBC Radio 5 live, begins at 11.15pm (local) on Wednesday and will be available on the BBC Sport website.